吕军鸿
教 授
学历/学位
博士
职称
教 授
电子邮箱
Lvjunhong@ytu.edu.cn
招生专业/类别
学/专硕（药学、生物与医药（制药工程）
一、基本情况
吕军鸿，博士，教授，Lvjunhong@ytu.edu.cn。
二、目前研究领域
以生物界面科学前沿为导向，整合生物物理（太赫兹/红外光谱与成像、原子力显微镜单细胞成像）与纳米递送技术（纳米气泡、脂质纳米粒LNPs），系统解析生物与药学中的关键界面问题。
重点聚焦：
细胞膜界面稳态对干细胞衰老的调控与干预策略；
肠界面微生态调控及其与代谢健康的关系。
欢迎具有药学、化学、物理、生物学或相关交叉学科背景的同学！
三、学习及工作经历
中国科学院研究生院，博士生
中国科学院上海应用物理所 助研、副研、研究员
美国哈佛大学（医学院、米兰研究所） Research Fellow
英国牛津大学化学系 玛丽居里学者
中国科学院上海高等研究院 研究员 PI
山东滨州医学院 特聘教授
烟台大学药学院 黄海学者特聘教授
济南微生态生物医学省实验室 客座教授（PI）
四、社会兼职
兼任：中国生物物理学会太赫兹分会副会长、中国老年保健医学研究会氢分子生物医学分会常务委员、中国颗粒学会微纳气泡专业委员会委员、中国抗衰老促进会标准委员会委员
五、主要科研成果
Navigating the unknown: Nanobubbles and the hidden complexity of aerophilic surfaces. PNAS, 2026
Decoding Biofilm-Surface Interactions: A Hyperspectral Infrared Platform Links Interfacial Chemistry to Stress Adaptation and Assembly Mechanism. Langmuir, 2026
Cu2+ triggers lipid phase separation in anionic membranes via a bimodal interfacial mechanism. Colloids and Surfaces B: Biointerfaces, 2026,357:115786.
Multiscale Chemical Cartography of Single Cells: Deconstructing Endothelial Heterogeneity with Synchrotron Infrared Microspectroscopy. Spectrochimica Acta Part A, 2026,357:127793.
Molecular hydrogen as a mitochondrial redox network modulator: a hypothesis on the transition from scavenger to signaling agent. Medical Hypotheses, 2026, 210, 111931.
Deciphering functional redundancy of lysine decarboxylases in probiotic E. coli Nissle 1917 via an integrated CRISPR-FTIR phenomics platform. Spectrochimica Acta Part A, 2026,351:127508.
Gas therapy for anti-biofilm applications. Medical Gas Research,2026,16(3):263-268.
Rapid Phenotypic Screening of Lysine-Degrading Probiotics via FTIR Spectroscopy: Towards Precision Therapy for Hyperlysinemia. ACS Synthetic Biology,2026.
Unexpected Enhancement of Antibacterial Activity of Copper Ions in the Presence of Nanobubbles. Langmuir,2026,42:1159-1166.
Blood coagulation protein binds to calcium ion-induced phosphatidylserine nanodomains as revealed by atomic force microscopy. BBA-biomembrane, 2026, 1868:184500.
Targeting conserved dynamic regions of SARS-CoV-2 spike protein identified by normal mode analysis for broad-spectrum antiviral therapy. Medical Hypotheses, 2026, 207, 111873.
Single-Cell Infrared Microspectroscopy Reveals Biochemical Heterogeneity Between Two Central Nervous System Tumors. Talanta, 2026, 298, 128978.
Near-field terahertz nanoscopy spatially resolves chiral drug-cell interactions: Toward Precision Intracellular Pharmacology. Analytical Chemistry,2025, 97, 12408−12418.
T7 Endonuclease I-mediated single-base mismatch biosensing strategy for high-resolution quantitative analysis of 5-hydroxymethylcytosine in genomic DNA. JACS Au, 2025, 5, 1320−1327
Terahertz s‑SNOM Imaging of a Single Cell with Nanoscale Resolution. Nano Letters,2024, 24, 7757−7763.
Engineered probiotic cocktail with two cascade metabolic Escherichia coli for the treatment of hydrolysineemia. Front. Microbiol. 2024, 15:1366017.
Comparative analysis of biofilm characterization of probiotic Escherichia coli. Front. Microbiol., 2024, 15: 1365562.
Vibrational phenomics decoding of the stem cell stepwise aging process at single-cell resolution. ChemComm.2024, 60:3263-3266.
Terahertz irradiation improves cognitive impairments and attenuates Alzheimer’s neuropathology in APP SWE /PS1 DE9 mouse: A novel therapeutic intervention for Alzheimer’s disease, Neurosci. Bull.2024,40, 857-871.
SUN1/2 Controls Macrophage Polarization via Modulating Nuclear Size and Stiffness. Nature Communications. 2023, 14:6416.
Nanobubble can modulate microbial communities and sedimentary ecosystem during the treatment of pond water. Environ. Sci.: Water Res. Technol. 2023, 9:1804–1812.
Hydrogel microenvironment contributes to chemical-induced differentiation of Mesenchymal stem cells: Single cell infrared microspectroscopy characterization. Anal Bioanal Chem.2023,415(17): 3305-3312.
Label-free analysis of biofilm phenotypes by infrared micro- and correlation- spectroscopy. Anal Bioanal Chem. 2023,415 (17):3515-3523.
An antioxidation strategy based on ultra-small nanobubbles without exogenous antioxidants. Sci Rep. 2023,13(1):8455.
Single-cell infrared phenomics identifies cell heterogeneity of individual pancreatic Islets in mouse model. Anal Chim Acta.2023,1258:341185,
Protopanaxadiol manipulates gut microbiota to promote bone marrow hematopoiesis and enhance immunity in cyclophosphamide-induced immunosuppression mice. MedComm, 2023,4: e222.
Oxygen therapy accelerates apoptosis induced by selenium compounds via regulating Nrf2/MAPK signaling pathway in hepatocellular carcinoma. Pharmacological Research, 2023, 187:106624.
指导研究生情况
已毕业 21 名，在读 6 名。
