烟台大学药学院 药学院 School of Pharmacy
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宋志花

高级实验师

  • 学历/学位

    博士

  • 职称

    高级实验师

  • 电子邮箱

    zhihuasong08@yeah.net

  • 招生专业/类别

    药学-药物分析、专硕和学硕

一、基本情况

宋志花，博士，高级实验师，zhihuasong08@yeah.net。

二、目前研究领域

针对强极性药物及其他类型药物分离分析问题，采用色谱分析法开展新型分离材料设计、合成及相关机理研究，并设计、组装及评价试纸条以筛选快速检测方法。

三、学习及工作经历

  • 内蒙古大学（本科）

  • 中国科学院大连化学物理研究所（硕博连读）

  • 中国科学技术大学（专业理论学习）

  • 烟台大学 药学院

四、社会兼职

  • Journal of Analysis and Testing (JAT)青年编委、《化学试剂》期刊青年编委； Food Chemistry, Analytica Chimica Acta, Talanta, J. Chromatogr. A, ACS Applied Nano Materials 等期刊审稿人。

五、主要科研成果

主持国家级、山东省、烟台市等各类项目共8 项，获授权国家发明专利6 件，以第一作者或通讯作者发表SCI 论文20 余篇，其中高被引用论文2 篇。

  1. [1] 2025.01-2027.12，国家自然科学基金，青年项目，30 万元；

  2. [2] 2025.01-2027.12，山东省自然科学基金，青年项目，12 万元；

  3. 烟台市科技发展计划项目, 20 万元(已通过验收, 项目号：2020MSGY112).

  4. 烟台大学博士科研启动基金, 12 万元(在研，项目号：YX20B39).

  5. 横向课题, 10 万元(在研，项目号：YX22KH2447).

六、发表论文

  1. Zhihua Song*(宋志花, 第一作者, 通讯作者), Wenpu Wu, Lei Sui, Xinyan Han, Hui Xu, Gangqiang Yang, Peng Zhang, Na Zhou, Lingxin Chen, Jinhua Li*. Design and synthesis of fluorine-containing embedded carbon dots stationary phase for separation of versatile analytes. Anal. Chem., 2024, 96, 16590-16598. (SCI 一区, 自然指数期刊，TOP 期刊)

  2. Zhihua Song*(宋志花, 第一作者, 通讯作者), Yimeng Zhang, Guo Wei, Mingxuan Zhang, Lei Sui, Jinhua Li, Lingxin Chen*. Lateral flow chromatography strip system for rapid fluorescence determination of phycocyanin in water samples. J. Hazard. Mater., 2024, 480, 135927. (SCI 一区, TOP 期刊)

  3. Guo Wei, Chuanliang Wang, Rui Wang, Xuhui Geng, Jinhua Li*, Lingxin Chen, Zhihua Song*(宋志花, 通讯作者). Novel carbon dots-based system for “on-off-on” fluorescence consecutive sensing of Au3+ and L-Cys. Food Chem., 2025, 495, 146303. (SCI 一区, TOP 期刊)

  4. Yimeng Zhang, Chuanliang Wang, Guo Wei, Xuesong Wang, Wanhui Liu, Gangqiang Yang, Peng Zhang, Qinglian Li, Xuhui Geng*, Lingxin Chen, Zhihua Song* (宋志花, 通讯作者). Facile fluorescence detection of malachite green in fish using molecularly imprinted polymers doped CdTe quantum dots based system. Food Chem., 2024, 442, 138458. (SCI 一区, TOP 期刊)

  5. Zhihua Song*(宋志花, 第一作者, 通讯作者), Yanqin Song, Yinghao Wang, Jinqiu Liu, Yumeng Wang, Wen Lin, Yaqi Wang, Jinhua Li, Jiping Ma, Gangqiang Yang*, Lingxin Chen*. Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases. Talanta, 2022, 239, 123115. (SCI 一区, TOP 期刊, IF: 6.1)

  6. Zhihua Song* (宋志花, 第一作者, 通讯作者), Jinhua Li, Wenhui Lu, Bowei Li*, Gangqiang Yang, Yi Bi, Maryam Arabi, Xiaoyan Wang, Jiping Ma, Lingxin Chen*. Molecularly imprinted polymers based materials and their applications in chromatographic and electrophoretic separations. TrAC Trend. Anal. Chem., 2022, 146, 116504. (SCI 一区, TOP 期刊, IF: 13.1)

  7. Lei Sui, Shuo Wang, Guo Wei, Na Zhou, Lingxin Chen*, Zhihua Song* (宋志花, 通讯作者). Fabrication of N, F-carbon dots doped fluorine-containing stationary phase for diversified analytes. J Anal. Test., https://doi.org/10.1007/s41664-026-00428-8. (中科院一区TOP)

  8. Peijun Chai, Xuhui Geng, Ruirui Zhu, Wenpu Wu, Xuesong Wang, Jinhua Li, Longwen Fu, Hongdan Wang, Wanhui Liu,* Lingxin Chen,* Zhihua Song*(宋志花, 通讯作者). Fabrication and application of molecularly imprinted polymer doped carbon dots coated silica stationary phase. Anal. Chim. Acta, 2023, 1275, 341611. ( SCI 二区, TOP 期刊, IF: 5.7)

  9. Zhihua Song* (宋志花, 第一作者, 通讯作者), Jinhua Li, Wenhui Lu, Bowei Li, Jinqiu Liu, Yaqi Wang, Yumeng Wang, Zhong Zhang, Lingxin Chen*. Synthesis and evaluation of fosfomycin group end-capped packing materials for hydrophilic interaction liquid chromatography. J. Chromatogr. A, 2021, 1656, 462529.( SCI 二区, TOP 期刊, IF: 4.601)

  10. Zhihua Song*# (宋志花, 第一作者, 通讯作者), Shenghong Li#, Yafeng Guan, Shuo Wang, Yinghao Wang, Gangqiang Yang, Xiaochen Zhang, Jinhua Li, Wenhao Song, Chuanming Zhou, Lingxin Chen*. Facile synthesis of zirconia-coated mesoporous silica particles by hydrothermal strategy under low potential of hydrogen conditions and functionalization with dodecylphosphonic acid for high-performance liquid chromatography. J. Chromatogr. A, 2020, 1612, 460659. (SCI 二区, TOP 期刊, IF: 4.759)

  11. Guo Wei, Yimeng Zhang, Rui Wang, Chuanliang Wang, Xuhui Geng, Peng Zhang, Jinhua Li, Lingxin Chen*, Zhihua Song* ( 宋志花, 通讯作者). Molecularly imprinted polymer-based system for simultaneous fluorescence quantification of malachite green and crystal violet. Microchim. Acta, 2025, 192, 626. (SCI 二区)

  12. Zhihua Song*(宋志花, 第一作者, 通讯作者), Jinqiu Liu, Deyang Zhang*, Yumeng Wang, Wen Lin, Yi Bi, Hongbo Wang, Maryam Arabi, Jinhua Li, Jiping Ma, Lingxin Chen*. Synthesis of fluorine-containing stationary phases for chromatographic separation of highly polar compounds. Microchem. J. 2022, 181, 107670. (SCI 二区, IF: 5.304)

  13. Guangli Zhao, Yue Zhang, Dani Sun, Shili Yan, Yuhao Wen, Junhua Jia, Yixiao Wang, Guisheng Li*, Huitao Liu, Jinhua Li*, Zhihua Song*(宋志花, 通讯作者). Recent Advances in Molecularly Imprinted Polymers for Antibiotic Analysis. Molecules, 2023, 28, 335. (SCI 二区, IF: 4.927)

  14. Guo Wei, Rui Wang, Peile Cao, Peng Zhang, Jinhua Li*, Lingxin Chen, Zhihua Song* (宋志花, 通讯作者). Colorimetric and fluorometric dual-response system for rapid analysis of gentamicin in real samples. Spectrochim. Acta A, 2026, 350, 127461. (SCI 二区)

  15. Guo Wei, Chuanliang Wang, Rui Wang, Peng Zhang, Xuhui Geng, Jinhua Li, Abbas Ostovan, Lingxin Chen, Zhihua Song* (宋志花, 通讯作者). Sensitive and facile detection of Aloin via N,F-CD-coated test strips coupled with a miniaturized fluorimeter. Biomolecules, 2025, 15, 1052. (SCI 二区, IF: 4.8)

  16. Rui Wang, Junping Xue, Guo Wei, Yimeng Zhang, Chuanliang Wang, Jinhua Li, Xuhui Geng, Abbas Ostovan, Lingxin Chen, Zhihua Song*(宋志花, 通讯作者). Fast and sensitive detection of anti-SARS-CoV-2 IgG using SiO2@Au@CDs nanoparticle-based lateral flow immunoassay strip coupled with miniaturized fluorimeter. Biomolecules 2024, 14, 1568. (SCI 二区, IF: 4.8)

  17. Wenpu Wu, Cuichi Yu, Lei Sui, Hui Xu*, Jinhua Li, Na Zhou, Lingxin Chen*, Zhihua Song* (宋志花, 通讯作者). Molecularly imprinted polymer-coated silica microbeads for high-performance liquid chromatography. Analyst, 2024,149, 3765-3772.

  18. Junping Xue, Jingxiu Zhang, Cuichi Yu, Maryam Arabi, Jinhua Li, Guisheng Li*, Gangqiang Yang, Lingxin Chen, Zhihua Song* (宋志花, 通讯作者). Synthesis and evaluation of ginsenosides imprinted polymer-based chromatographic stationary phase. J. Sep. Sci, 2023, 2200825.

  19. Zhihua Song* (宋志花, 第一作者, 通讯作者), Shenghong， Gangqiang Yang， Na Zhou， Lingxin Chen*. Sample pretreatment, analysis and detection of ginsenosides. Prog. Chem., 2020, 32(2/3), 239-248.

  20. Milan Wang ＃, Zhihua Song ＃ （宋志花, 共同第一作者）, Youwei Jiang, Xiaolin Zhang, Lin Wang, Hongyu Zhao, Yutong Cui, Furong Gu, Yunhua Wang*, Guoxia Zheng*. A three-dimensional pinwheel-shape paper-based microfluidic analytical device for fluorescence detection of multiple heavy metals in coastal waters by rational device design. Anal. Bioanal. Chem., 2021, 413, 3299-3313. (影响因子: 4.478)

七、授权专利情况

  1. 一种生物碱类化合物用硅胶液相色谱填料的制备方法, ZL 201911048589.1.

  2. 一种用于极性药物分离的含氟液相色谱填料及其制备方法, ZL 2022 1 0512304.0.

  3. 一种碳量子点掺杂液相色谱填料及其制备方法和应用, ZL 2021 1 1459253.1.

  4. 氮氟元素掺杂的碳点及其制备方法和应用, ZL 202411024847.3.

  5. 一种检测新型冠状病毒抗体的免疫层析试纸条, ZL 202211031293.0.

  6. 一种含氟碳点键合硅胶色谱固定相及其制备方法和应用, ZL 202510361952.4

指导研究生情况

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