吕军鸿

教授

• 学历/学位

  博士

• 职称

  教授

• 电子邮箱

  Lvjunhong@ytu.edu.cn

• 招生专业/类别

  学/专硕（药学、生物与医药（制药工程））

一、基本情况

吕军鸿，博士，教授，烟台大学药学院黄海学者特聘教授，以生物界面科学前沿为导向开展生物物理与纳米递送技术研究。

二、学习及工作经历

• 2001-2004

  中国科学院研究生院，博士生

• 2004-2018

  中国科学院上海应用物理所，助研、副研、研究员

• 2007-2012

  美国哈佛大学（医学院、米兰研究所），Research Fellow

• 2013-2015

  英国牛津大学化学系，玛丽·居里学者

• 2018-2023

  中国科学院上海高等研究院，研究员 PI

• 2018-2025

  山东滨州医学院，特聘教授

• 2025-今

  烟台大学药学院，黄海学者特聘教授

• 2020-今

  济南微生态生物医学省实验室，客座教授（PI）

三、社会兼职

• 中国生物物理学会太赫兹分会副会长

• 中国老年保健医学研究会氢分子生物医学分会常务委员

• 中国颗粒学会微纳气泡专业委员会委员

• 中国抗衰老促进会标准委员会委员

四、目前研究领域

以生物界面科学前沿为导向，整合生物物理（太赫兹/红外光谱与成像、原子力显微镜单细胞成像）与纳米递送技术（纳米气泡、脂质纳米粒LNPs），系统解析生物与药学中的关键界面问题。重点聚焦：1、细胞膜界面稳态对干细胞衰老的调控与干预策略；2、肠界面微生态调控及其与代谢健康的关系。欢迎具有药学、化学、物理、生物学或相关交叉学科背景的同学！

五、代表性科研项目、成果和奖励

1. Navigating the unknown: Nanobubbles and the hidden complexity of aerophilic surfaces. PNAS, 2026

2. Decoding Biofilm-Surface Interactions: A Hyperspectral Infrared Platform Links Interfacial Chemistry to Stress Adaptation and Assembly Mechanism. Langmuir, 2026

3. Cu2+ triggers lipid phase separation in anionic membranes via a bimodal interfacial mechanism. Colloids and Surfaces B: Biointerfaces, 2026, 357: 115786.

4. Multiscale Chemical Cartography of Single Cells: Deconstructing Endothelial Heterogeneity with Synchrotron Infrared Microspectroscopy. Spectrochimica Acta Part A, 2026, 357: 127793.

5. Molecular hydrogen as a mitochondrial redox network modulator: a hypothesis on the transition from scavenger to signaling agent. Medical Hypotheses, 2026, 210, 111931.

6. Deciphering functional redundancy of lysine decarboxylases in probiotic E. coli Nissle 1917 via an integrated CRISPR-FTIR phenomics platform. Spectrochimica Acta Part A, 2026, 351: 127508.

7. Gas therapy for anti-biofilm applications. Medical Gas Research, 2026, 16(3): 263-268.

8. Rapid Phenotypic Screening of Lysine-Degrading Probiotics via FTIR Spectroscopy: Towards Precision Therapy for Hyperlysinemia. ACS Synthetic Biology, 2026

9. Unexpected Enhancement of Antibacterial Activity of Copper Ions in the Presence of Nanobubbles. Langmuir, 2026, 42: 1159-1166.

10. Blood coagulation protein binds to calcium ion-induced phosphatidylserine nanodomains as revealed by atomic force microscopy. BBA-biomembrane, 2026, 1868: 184500.

11. Targeting conserved dynamic regions of SARS-CoV-2 spike protein identified by normal mode analysis for broad-spectrum antiviral therapy. Medical Hypotheses, 2026, 207, 111873.

12. Single-Cell Infrared Microspectroscopy Reveals Biochemical Heterogeneity Between Two Central Nervous System Tumors. Talanta, 2026, 298, 128978.

13. Near-field terahertz nanoscopy spatially resolves chiral drug-cell interactions: Toward Precision Intracellular Pharmacology. Analytical Chemistry, 2025, 97, 12408-12418.

14. T7 Endonuclease I-mediated single-base mismatch biosensing strategy for high-resolution quantitative analysis of 5-hydroxymethylcytosine in genomic DNA. JACS Au, 2025, 5, 1320-1327.

15. Terahertz s-SNOM Imaging of a Single Cell with Nanoscale Resolution. Nano Letters, 2024, 24, 7757-7763.

16. Engineered probiotic cocktail with two cascade metabolic Escherichia coli for the treatment of hyperlysinemia. Front. Microbiol. 2024, 15: 1366017.

17. Comparative analysis of biofilm characterization of probiotic Escherichia coli. Front. Microbiol., 2024, 15: 1365562.

18. Vibrational phenomics decoding of the stem cell stepwise aging process at single-cell resolution. ChemComm. 2024, 60: 3263-3266.

19. Terahertz irradiation improves cognitive impairments and attenuates Alzheimer’s neuropathology in APP SWE/PS1 DE9 mouse: A novel therapeutic intervention for Alzheimer’s disease, Neurosci. Bull. 2024, 40, 857-871.

20. SUN1/2 Controls Macrophage Polarization via Modulating Nuclear Size and Stiffness. Nature Communications. 2023, 14: 6416.

21. Nanobubble can modulate microbial communities and sedimentary ecosystem during the treatment of pond water. Environ. Sci.: Water Res. Technol. 2023, 9: 1804-1812.

22. Hydrogel microenvironment contributes to chemical-induced differentiation of Mesenchymal stem cells: Single cell infrared microspectroscopy characterization. Anal Bioanal Chem. 2023, 415(17): 3305-3312.

23. Label-free analysis of biofilm phenotypes by infrared micro- and correlation-spectroscopy. Anal Bioanal Chem. 2023, 415(17): 3515-3523.

24. An antioxidation strategy based on ultra-small nanobubbles without exogenous antioxidants. Sci Rep. 2023, 13(1): 8455.

25. Single-cell infrared phenomics identifies cell heterogeneity of individual pancreatic Islets in mouse model. Anal Chim Acta. 2023, 1258: 341185.

26. Protopanaxadiol manipulates gut microbiota to promote bone marrow hematopoiesis and enhance immunity in cyclophosphamide-induced immunosuppression mice. MedComm, 2023, 4: e222.

27. Oxygen therapy accelerates apoptosis induced by selenium compounds via regulating Nrf2/MAPK signaling pathway in hepatocellular carcinoma. Pharmacological Research, 2023, 187: 106624.

六、指导研究生情况

已毕业21名，在读6名。