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教授

[教授][博士]赵烽
添加时间:2015-10-26 11:35
姓名 赵烽 籍贯 河北省 最后学历 研究生
最后毕业院校 沈阳药科大学 所学专业 药物化学
工作单位 烟台大学药学院 职称/职务 教授
办公电话 0535-6706021 电子邮件 ytuzhaofeng@163.com
目前研究
方向简介
1、阐明中药的药效物质基础
2、天然药物活性成分及其生物活性、构效关系、作用机制研究。
近五年主持(或参与)教学、科研项目 (1) 主持国家自然科学基金1项(苦木药效物质基础β-卡波林生物碱对炎性信号传导通路的调控81102781,22万元)
(2) 主持国家科技部科技型中小企业技术创新项目1项(肿瘤新靶点蛋白酪氨酸激酶定量酶联免疫试剂盒,70万元)
(3) 主持完成山东省自然科学基金面上项目1项(腺梗豨莶抗炎作用物质基础前炎症因子抑制活性成分的研究ZR2009CM029,5万元)
(4) 主持完成山东省优秀中青年科学家科研奖励基金1项(木香中倍半萜类化学成分的抗炎活性和构效关系的研究(2006BS02005,8万元)
(5) 主持真菌学国家重点实验室开放课题1项(鸟巢烷型二萜cyathatriol抗炎活性与作用机理研究,15万元)
(6) 参与国家自然科学基金面上项目1项(基于尿液和胆汁中化学信息逆向追踪研究锦灯笼抗炎药效物质基础及其作用机制81274039,第2位,75万元)
(7) 参与完成山东省优秀中青年科学家科研奖励基金1项(木香倍半萜抑制VEGF活性及构效关系研究2007BS02005,第2位,8万元)
(8) 参与完成山东省教育厅科技计划项目1项(呋喃二烯的抗癌活性及机理研究J07W01,第2位,8万元)
(9) 参与山东省自然科学基金面上项目1项(二种黄芩属植物中新克罗烷型二萜的发现及抗肿瘤活性研究ZR2013HM023,第2位,10万元)
(10) 参与完成山东省科技攻关计划项目1项(新靶点抗肿瘤药筛选平台的构建与先导化合物筛选2006GG2202049,第3位,10万元)。
(11) 主持横向课题3项,横向课题协议到位经费总金额28万元。
近五年教学、科研获奖
及专利
(1)2011年1月获山东省科学技术奖三等奖(源于传统中药的抗肿瘤创新药物研究与开发,第5位)
(2)2009年12月获山东省高等学校优秀科研成果奖三等奖(木香倍半萜化学成分的抗炎活性和构效关系的研究,第1位)
(3)2012年5月获第六届烟台市青年科技奖
(4)2009年6月获烟台大学科学技术进步奖二等奖(木香倍半萜化学成分的抗炎活性和构效关系的研究,第1位)
(5)已申请发明专利14项
近五年已发表的代表性论著 1.         Zhao F*(赵烽), Hu Y, Lu M, Chong C, Li L, Chen L, Kan W, Chen L, Liu H. Ardisiphenol D, a resorcinol derivative identified from Ardisia brevicaulis, exerts antitumor effect through inducing apoptosis in human non-small-cell lung cancer A549 cells. Pharmaceutical Biology. 2014, 52(7): 797-803.
2.         Zhao F*(赵烽), Chen L, Zhang M, Bi C, Li L, Zhang Q, Shi C, Li M, Zhou S, Kong L. Inhibition of lipopolysaccharide-induced iNOS and COX-2 expression by indole alkaloid, 3-(hydroxymethyl)-6,7-dihydroindolo[2,3-a]quinolizin- (12H)-one, via NF-κB inactivation in RAW 264.7 macrophages. Planta Med. 2013, 79(9): 782-7. 
3.         Zhao F*(赵烽), Chen L, Bi C, Zhang M, Jiao W, Yao X. In vitro anti-inflammatory effect of picrasmalignan A by the inhibition of iNOS and COX-2 expression in LPS‑activated macrophage RAW 264.7 cells. Mol Med Rep. 2013, 8(5): 1575-9.
4.         Zhao F*(赵烽), Gao ZT, Jiao WH, Chen LL, Chen L, Yao XS. In vitro anti-inflammatory effects of beta-carboline alkaloids, isolated from Picrasma quassioides, through inhibition of the iNOS pathway. Planta Med. 2012, 78(18): 1906-11.
5.         Fan H, Qi D, Yang M, Fang H, Liu K, Zhao F*(赵烽, 通讯作者). In vitro and in vivo anti-inflammatory effects of 4-methoxy-5-hydroxycanthin-6-one, a natural alkaloid from Picrasma quassioides. Phytomedicine. 2013, 20(3-4): 319-23.
6.         Song Y, Zhao F(赵烽,共同第一作者), Zhang L, Du Y, Wang T, Fu F*. Ginsenoside Rg1 exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vitro. Fitoterapia. 2013, 91: 173-9. 
7.         Liu Y, Ma J, Zhao Q, Liao C, Ding L, Chen L, Zhao F*(赵烽, 通讯作者). Qiu F*. Guaiane-type sesquiterpenes from Curcuma phaeocaulis and their inhibitory effects on nitric oxide production. J Nat Prod. 2013, 76(6): 1150-6. 
8.         Yang L, Peng K, Zhao S, Zhao F(赵烽), Chen L*, Qiu F*. 2-methyl-L-erythritol glycosides from Gardenia jasminoides. Fitoterapia. 2013, 89: 126-30. 
9.         Peng K, Yang L, Zhao S, Chen L, Zhao F*(赵烽,通讯作者), Qiu F*. Chemical constituents from the fruit of Gardenia jasminoides and their inhibitory effects on nitric oxide production. Bioorg Med Chem Lett. 2013, 23(4): 1127-31. 
10.     Wang SJ, Bao L, Han JJ, Wang QX, Yang XL, Wen HA, Guo LD, Li SJ, Zhao F(赵烽), and Liu HW*. Pleurospiroketals A-E, Perhydrobenzannulated 5,5-spiroketal Sesquiterpenes from the edible Mushroom Pleurotus cornucopiae. J Nat Prod, 2013, 76(1), 45-50.
11.     Han J, Chen Y, Bao L, Yang X, Liu D, Li S, Zhao F(赵烽), Liu H*. Anti-inflammatory and cytotoxic cyathane diterpenoids from the medicinal fungus Cyathus Africanus. Fitoterapia, 2013, 84, 22-31.
12.     Li Y, Bao L, Song B, Han J, Li H, Zhao F(赵烽), Liu H. A new benzoquinone and a new benzofuran from the edible mushroom Neolentinus lepideus and their inhibitory activity in NO production inhibition assay. Food Chem. 2013, 141(3): 1614-8.
13.     Wang S, Bao L, Zhao F(赵烽), Wang Q, Li S, Ren J, Li L, Wen H, Guo L, Liu H. Isolation, Identification, and Bioactivity of Monoterpenoids and Sesquiterpenoids from the Mycelia of Edible Mushroom Pleurotus cornucopiae. J Agric Food Chem. 2013, 61(21): 5122-9. 
14.     Tao JY, Dai SJ, Zhao F(赵烽), Liu JF, Fang WS, Liu K. New ursane-type triterpene with NO production suppressing activity from Nauclea officinalis. J Asian Nat Prod Res. 2012,14(2): 97-104.
15.     Ding L, Jiang Z, Liu Y, Chen L, Zhao Q, Yao X, Zhao F*(赵烽,通讯作者), Qiu F*. Monoterpenoid inhibitors of NO production from Paeonia suffruticosa. Fitoterapia. 2012, 83(8): 1598-603. 
16.     Ding L, Liu Z, Zhao F(赵烽), Bai G, Chen L, Yao X, Qiu F*. Isolation and identification of the metabolites of paeonol in human urine. Xenobiotica. 2012, 42(12): 1206-12.
17.     Ding L, Zhao F(赵烽), Chen L, Jiang Z, Liu Y, Li Z, Qiu F, Yao X. New monoterpene glycosides from Paeonia suffruticosa Andrews and their inhibition on NO production in LPS-induced RAW 264.7 cells. Bioorg Med Chem Lett. 2012, 22(23): 7243-7. 
18.     Li J, Liao CR, Wei JQ, Chen LX, Zhao F*(赵烽,通讯作者), Qiu F*. Diarylheptanoids from Curcuma kwangsiensis and their inhibitory activity on nitric oxide production in lipopolysaccharide-activated macrophages. Bioorg Med Chem lett, 2011, 21: 5363-9.
19.     Chen LP, Zhao F(赵烽,通讯作者), Wang Y, Zhao LL, Li QP, Liu HW. Antitumor effect of resorcinol derivatives from the roots of Ardisia brevicaulis by inducing apoptosis. J Asian Nat Prod Res, 2011, 13(8): 734-43.
20.     Jiao WH, Gao H, Zhao F(赵烽), He F, Zhou GX, Yao XS. A New Neolignan and a New Sesterterpenoid from the Stems of Picrasma quassioides Bennet. Chem Biodivers, 2011, 8: 1163-9.
21.     Jiao WH, Gao H, Zhao F(赵烽), Lin HW, Pan YM, Zhou GX, Yao XS. Anti-inflammatory Alkaloids from the Stems of Picrasma quassioides Bennet. Chem Pharm Bull. 2011, 59(3): 359-64.
22.     Wu W, Zhao F(赵烽), Bao L, Lu J, Liu H*. Two new cryptoporic acid derivatives from the fruiting bodies of Cryptoporus sinensis. Helvetica Chimica Acta, 2011, 94(11): 2020-6.
23.     Yan S, Li S, Wu W, Zhao F(赵烽), Bao L, Ding R, Gao H, Wen HA, Song F, Liu HW*. Terpenoid and phenolic metabolites from the fungus Xylaria sp. associated with termite nests. Chem Biodivers, 2011, 8(9), 1689-700.
24.     Wu W, Zhao F(赵烽), Ding R, Bao L, Gao H, Lu J, Yao X, Zhang X, Liu H*. Four New Cryptoporic Acid Derivatives from the Fruiting Bodies of Cryptoporus sinensis, and Their Inhibitory Effects on Nitric-Oxide Production. Chem Biodivers, 2011, 8: 1529-38.
25.     Wang QX, Li SF, Zhao F(赵烽), Dai HQ, Bao L, Ding R, Gao H, Zhang LX, Wen HA, Liu HW*. Chemical constituents from endophytic fungus Fusarium oxysporum. Fitoterapia, 2011, 82(5): 777-81.
26.     Bao L, Wang M, Zhao F(赵烽), Zhao Y, Liu H*. Two New Resorcinol Derivatives with Strong Cytotoxicity from the Roots of Ardisia brevicaulis Diels. Chem Biodivers, 2010, 7(12): 2901-7.
27.     Li J, Zhao F (赵烽,通讯作者), Li MZ, Chen LX, Qiu F. Diarylheptanoids from the Rhizomes of Curcuma kwangsiensis. J Nat Prod, 2010, 73(10): 1667-71.
28.     Liu H, Zhao Y, Yang R, Zheng M, Wang M, Zhang X, Qiu F, Wang H, Zhao F(赵烽,通讯作者). Four new 1,4-benzoquinone derivatives and one new coumarin isolated from Ardisia gigantifolia. Hel Chim Acta. 2010, 93: 249-56.
29.     Tang JS, Zhao F(赵烽), Gao H, Dai Y, Yao ZH, Hong K, Li J, Ye WC, Yao XS. Characterization and online detection of surfactin isomers based on HPLC-MSn analyses and their inhibitory effects on the overproduction of nitric oxide and the release of TNF-α and IL-6 in LPS-induced macrophages. Mar Drugs, 2010, 8: 2605-18.
30.     Jiao WH, Gao H, Li CY, Zhao F(赵烽), Jiang RW, Wang Y, Zhou GX, Yao XS. Quassidines A-D, bis-beta-carboline alkaloids from the stems of Picrasma quassioides. J Nat Prod. 2010, 73(2): 167-71.
31.     Lou Y, Zhao F(赵烽), He H, Peng KF, Chen LX, Qiu F. Four new sesquiterpenes from Curcuma wenyujin and their inhibitory effects on nitric-oxide production. Chem Biodivers, 2010, 7(5): 1245-53.
32.     Zhao F(赵烽), Wang L, Liu K. In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway. J Ethnopharmacol, 2009, 122(3): 457-62.
33.     Zhou K, Zhao F(赵烽), Liu Z, Zhuang Y, Chen L, Qiu F*. Triterpenoids and flavonoids from celery (Apium graveolens). J Nat Prod, 2009, 72(9): 1563-7.
34.     Liu H, Zhao F(赵烽), Yang R, Wang M, Zheng M, Zhao Y, Zhang X, Qiu F, Wang H. Dimeric 1,4-benzoquinone derivatives and a resorcinol derivative from Ardisia gigantifolia. Phytochemistry, 2009, 70(6): 773-8.
35.     Gao H, Zhao F(赵烽), Chen GD, Chen SD, Yu Y, Yao ZH, Lau BW, Wang Z, Li J, Yao XS. Bidesmoside triterpenoid glycosides from Stauntonia chinensis and relationship to anti-inflammation. Phytochemistry, 2009, 70(6): 795-806.
36.     Lou Y, Zhao F(赵烽), Wu Z, Peng K, Wei X, Chen L, Qiu F. Germacrane-type sesquiterpenes from Curcuma wenyujin. Helv Chim Acta, 2009, 92: 1665-72.
37.     Lou Y, Zhao F(赵烽), He H, Peng KF, Zhou XH, Chen LX, Qiu F. Guaiane-type sesquiterpenes from Curcuma wenyujin and their inhibitory effects on nitric oxide production. J Asian Nat Prod Res, 2009, 11(8): 737-47.
38.     Sun XY, Zheng YP, Lin DH, Zhang H, Zhao F(赵烽), Yuan CS. Potential anti-cancer activities of furanodiene, a sesquiterpene from Curcuma wenyujin. Am J Chin Med, 2009, 37(3): 589-96.
学术兼职 美国癌症学会会员
日本药学会会员、日本生药学会会员
Phytochemistry, Planta Medica, Fitoterapia, Jpurnal of Natural Products, Journal of Asian Natural Products Research, Pharmceutical Biology等十几种SCI期刊源杂志审稿专家
指导研究生
情况
已毕业4名,在读3名。


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